The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Live donor kidney transplantation is the best treatment option for most patients with late-stage chronic kidney disease; however, the rate of living kidney donation has declined in the United States. A consensus conference was held June 5-6, 2014 to identify best practices and knowledge gaps pertaining to live donor kidney transplantation and living kidney donation. Transplant professionals, patients, and other key stakeholders discussed processes for educating transplant candidates and potential living donors about living kidney donation; efficiencies in the living donor (...) evaluation process; disparities in living donation; and financial and systemic barriers to living donation. We summarize the consensus recommendations for best practices in these educational and clinical domains, future research priorities, and possible public policy initiatives to remove barriers to living kidney donation. (shrink)

The purpose of this study was to evaluate, revise, and extend the Informed Consent Ontology (ICO) for expressing clinical permissions, including reuse of residual clinical biospecimens and health data. This study followed a formative evaluation design and used a bottom-up modeling approach. Data were collected from the literature on US federal regulations and a study of clinical consent forms. Eleven federal regulations and fifteen permission-sentences from clinical consent forms were iteratively modeled to identify entities and their relationships, followed by community (...) reflection and negotiation based on a series of predetermined evaluation questions. ICO included fifty-two classes and twelve object properties necessary when modeling, demonstrating appropriateness of extending ICO for the clinical domain. Twenty-six additional classes were imported into ICO from other ontologies, and twelve new classes were recommended for development. This work addresses a critical gap in formally representing permissions clinical permissions, including reuse of residual clinical biospecimens and health data. It makes missing content available to the OBO Foundry, enabling use alongside other widely-adopted biomedical ontologies. ICO serves as a machine-interpretable and interoperable tool for responsible reuse of residual clinical biospecimens and health data at scale. (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

Avoiding whinges from various and potentially conflicting stakeholders is a major challenge for sustainable development and for the identification of sustainability scenarios or policies for biodiversity and ecosystem services. It turns out that independently complying with whinge thresholds and constraints of these stakeholders is not sufficient because dynamic ecological-economic interactions and uncertainties occur. Thus more demanding no whinge standards are needed. In this paper, we first argue that these new boundaries can be endogenously exhibited with the mathematical concepts of viability (...) kernel and viable controls. Second, it is shown how these no whinge kernels have components, such as harvesting of resources, that should remain within safe corridor while some other components, in particular biodiversity, have only lower conservation limits. Thus, using radar charts, we show how this no whinge kernels can take the shape of a tree that we name viability tree. These trees of viability capture the idea that the unbounded renewal potential of biodiversity combined with a bounded use of the different ecosystem services are crucial ingredients for the sustainability of socio-ecosystems and the design of no whinge policies reconciling the different stakeholders involved. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Mutual perceptions of ethical behaviour among managers in nine EU-countries were quantatively measured and related to perceptions concerning "ease of cooperation". A strong positive correlation obtains: the more ethical a country is perceived to be, the higher it is valued as an international business partner. Germany, however, is a typical exception to this rule: German managers are perceived as the most ethical, but are considered relatively difficult to cooperate with.

From March 1841 until the end of 1845, W. R. Grove held the post of Professor of Experimental Philosophy at the London Institution. No previous study of the Institution has dealt in detail with the period of Grove's tenure of this, the first professorship. Here, by reference to the various manuscripts and publications of the Institution, and to Grove's papers and correspondence, it is possible to describe the background to Grove's appointment and the achievements of his term of office.

_Humanizing Education_ offers historic examples of humanizing educational spaces, practices, and movements that embody a spirit of hope and change. From Dayton, Ohio, to Barcelona, Spain, this collection of essays from the _Harvard Educational Review_ carries readers to places where people have first imagined—and then organized—their own educational responses to dehumanizing practices and conditions. Contributors include Montse Sánchez Aroca, William Ayers, Kathy Boudin, Fernando Cardenal, Jeffrey M. R. Duncan-Andrade, Marco Garrido, Jay Gillen, Maxine Greene, Kathe Jervis, Nancy Uhlar Murray, Valerie (...) Miller, Wendy Ormiston, Ana Y. Ramos-Zayas, Vanessa Siddle Walker, Arthur E. Thomas, and Travis Wright. (shrink)

Freely falling point-like objects converge toward the center of the Earth. Hence the gravitational field of the Earth is inhomogeneous, and possesses a tidal component. The free fall of an extended quantum mechanical object such as a hydrogen atom prepared in a high principal-quantum-number state, i.e. a circular Rydberg atom, is predicted to fall more slowly than a classical point-like object, when both objects are dropped from the same height above the Earth’s surface. This indicates that, apart from transitions between (...) quantum states, the atom exhibits a kind of quantum mechanical incompressibility during free fall in inhomogeneous, tidal gravitational fields like those of the Earth.A superconducting ring-like system with a persistent current circulating around it behaves like the circular Rydberg atom during free fall. Like the electronic wavefunction of the freely falling atom, the Cooper-pair wavefunction is quantum mechanically incompressible. The ions in the lattice of the superconductor, however, are not incompressible, since they do not possess a globally coherent quantum phase. The resulting difference during free fall in the response of the nonlocalizable Cooper pairs of electrons and the localizable ions to inhomogeneous gravitational fields is predicted to lead to a charge separation effect, which in turn leads to a large Coulomb force that opposes the convergence caused by the tidal gravitational force on the superconducting system.A “Cavendish-like” experiment is proposed for observing the charge separation effect induced by inhomogeneous gravitational fields in a superconducting circuit. The charge separation effect is determined to be limited by a pair-breaking process that occurs when low frequency gravitational perturbations are present. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

The pull to coordinate with other individuals is fundamental, serving as the basis for our social connectedness to others. Discussed is a dynamical and ecological perspective to joint action, an approach that embeds the individual’s mind in a body and the body in a niche, a physical and social environment. Research on uninstructed coordination of simple incidental rhythmic movement, along with research on goal‐directed, embodied cooperation, is reviewed. Finally, recent research is discussed that extends the coordination and cooperation studies, examining (...) how synchronizing with another, and how emergent social units of perceiving and acting are reflected in people’s feelings of connection to others. (shrink)

Developments in medical big data analytics may bring societal benefits but are also challenging privacy and other ethical values. At the same time, an overly restrictive data protection regime can form a serious threat to valuable observational studies. Discussions about whether data privacy or data solidarity should be the foundational value of research policies, have remained unresolved. We add to this debate with an empirically informed ethical analysis. First, experiences with the implementation of the General Data Protection Regulation (GDPR) within (...) a European research consortium demonstrate a gap between the aims of the regulation and its effects in practice. Namely, strictly formalised data protection requirements may cause routinisation among researchers instead of substantive ethical reflection, and may crowd out trust between actors in the health data research ecosystem; while harmonisation across Europe and data sharing between countries is hampered by different interpretations of the law, which partly stem from different views about ethical values. Then, building on these observations, we use theory to argue that the concept of trust provides an escape from the privacy-solidarity debate. Lastly, the paper details three aspects of trust that can help to create a responsible research environment and to mitigate the encountered challenges: trust as multi-agent concept; trust as a rational and democratic value; and trust as method for priority setting. Mutual cooperation in research—among researchers and with data subjects—is grounded in trust, which should be more explicitly recognised in the governance of health data research. (shrink)

If “Big Gods” evolved in part because of their ability to morally regulate groups of people who cannot count on kin or reciprocal altruism to get along, then powerful gods would tend to be good gods. If the mechanism for this cooperation is some kind of fear of supernatural punishment, then we may expect that mighty gods tend to be punishing gods. The present study is a statistical analysis of superhuman being concepts from 20 countries on five continents to explore (...) whether the goodness of a god is related to its mightiness. Gods that looked more like the God of classical theism and gods that were low in anthropomorphism were more likely to be regarded as morally good and to be the target of religious practices. Mighty gods were not, however, especially likely to punish or to be a “high god.”. (shrink)

This small anthology contains thirteen essays by eleven authors on the question: What are the defining characteristics of morality? What makes a judgment, an attitude, or an argument a moral one? The selection of articles is excellent. Ethicians included are: C. H. Whitely, A. MacIntyre, W. K. Frankena, C. C. W. Taylor, Neil Cooper, P. F. Strawson, T. L. S. Sprigge, P. Foot, K. Baier, G. E. M. Anscombe, D. F. Gauthier. An obvious objection to the pursuit of a (...) definition would be to suggest, as Whitely does, that there are no defining traits for all uses of "moral" or "morality": one can hope only to find family resemblances in the uses of the words. Others insist that there is a more precise and consistent use of these notions in ordinary language, though there may be different senses of the word moral, each with sufficiently clear defining traits. In a useful introduction that provides a unifying background for the essays, the editors suggest that six chief candidates appear for the role of the leading characteristic of morality: moral rules and principles can be defined by reference to their capacity for universality, their prescriptivity, their overriding force, the importance they have, the forms of sanctions appealed to, or by reference to their content. The authors in their essays do not, of course, define morality simply in terms of any one of these features; but they do stress or deny the importance of each of these features. Students will find this a helpful work, and there is a good bibliography.--R. D. L. (shrink)

This article argues that we could improve the design of research protocols by developing an awareness of and a responsiveness to the social contexts of all the actors in the research enterprise, including subjects, investigators, sponsors, and members of the community in which the research will be conducted. ?Social context? refers to the settings in which the actors are situated, including, but not limited to, their social, economic, political, cultural, and technological features. The utility of thinking about social contexts is (...) introduced and exemplified by the presentation of a hypothetical case in which one central issue is limitation of the probability of injury to subjects by selection of individuals who are not expected to live long enough for the known risks of the study to become manifest as harms. Benefits of such considerations may include enhanced subject satisfaction and cooperation, community acceptance, and improved data quality, among other desirable consequences. (shrink)

This article argues that we could improve the design of research protocols by developing an awareness of and a responsiveness to the social contexts of all the actors in the research enterprise, including subjects, investigators, sponsors, and members of the community in which the research will be conducted. “Social context” refers to the settings in which the actors are situated, including, but not limited to, their social, economic, political, cultural, and technological features. The utility of thinking about social contexts is (...) introduced and exemplified by the presentation of a hypothetical case in which one central issue is limitation of the probability of injury to subjects by selection of individuals who are not expected to live long enough for the known risks of the study to become manifest as harms. Benefits of such considerations may include enhanced subject satisfaction and cooperation, community acceptance, and improved data quality, among other desirable consequences. (shrink)

Le livre-testament d'un des plus grands écologues français qui nous offre un plaidoyer limpide et convaincant pour nous aider à nous réconcilier avec la nature avec notre nature et à nous construire ainsi un autre avenir. L'homme fait partie de la nature, au même titre que les autres mammifères, les insectes, les plantes... Pendant des milliards d'années, tous ces organismes ont évolué, se sont adaptés, sont parfois entrés en compétition les uns avec les autres, et surtout ont coopéré. Là se (...) trouve la raison principale du remarquable succès du monde vivant, comme le montrent de nombreux exemples concret : si les tensions et les conflits existent bien entre les espèces, la nature est surtout un lieu d'échanges, d'entraide, de coopération. Mais l'emprise grandissante d'une espèce particulière, la nôtre, bouleverse cet équilibre subtil : l'homme est devenu une menace pour la planète, ses habitants et lui-même. Pour autant, il n'est pas trop tard pour redresser le cap! C'est en reconnaissant que nous faisons tous partie d'une même communauté, en développant une nouvelle solidarité écologique, en nous réconciliant avec le monde vivant que nous pourrons le sauver : réconcilions-nous avec la nature, car c'est notre nature! (shrink)

In lieu of an abstract, here is a brief excerpt of the content: Choice and Virtue in the Nicomachean Ethics ALFRED R. MELE COM~rNTATORS ON THr Nicomachean Ethics (NE) have long been laboring under the influence of a serious misunderstanding of one of the key terms in Aristotle's moral philosophy and theory of action. This term is prohairesis (choice), the importance of which is indicated by Aristotle's assertions that choice is the proximate efficient cause of action (NE 6. 1139a31--32) and (...) that in which "the essential elements of virtue and character" lie (NE 8. x163a2'~-23). The accepted view is that Aristotle employs two importantly different notions of choice in the NE, one on which the term refers exclusively to means or things which are pros (toward, related to)' ends and another on which it does not have this reference? This "two notion" interpretation is motivated by the following three considerations: i. Aristotle's good or virtuous agent is said (NE 2. 11o5a28-33, cf. NE 6. 1144ax8-2o ) to choose actions for their own sakes; but, according to the This paper is derived in part from a chapter of my doctoral dissertation, which was submitted to the University of Michigan in January of 1979. 1 would like to express my gratitttde to the chairman of my dissertation committee, Nicholas P. White, for his comments and criticisms on the relevant sections during the preparation of my dissertation and to theJHP's anonymous reviewers for their helpful criticisms and queries. ' It has often been pointed out that things which are pros an end are not necessarily "means," in the ordinary sense of the word. E.g., constituents of an end are pros the end, but they are not means to it. See, e.g., Nicomachean Ethics, Book 6, trans. Leonard H. G. Greenwood (Cambridge: Cambridge University Press, 19o9), pp. 46-47, 53ff.: and John M. Cooper, Reason and Human Good in Aristotle (Cambridge: Harvard University Press, 1975), pp. 1o-22. ' Among the many proponents of this "two notion" interpretation are William D. Ross and Donald J. Allan. See Ross, Aristotle, 5th ed. (London: Methuen, t953), p. 2oo. See Allan, The Philosophy of Aristotle, 2nd ed. (London: Oxford University Press, 197o), p. 132; idem, "Aristotle 's Account of the Origin of Moral Principles," Xlth International Congress of Philosophy 12 (1953):124; idem, "The Practical Syllogism," in Autour d'Aristote, Studies for A. Mansion (Louvain : Publications Universitaires, 1955). Richard Sorabji, in "Aristotle on the Role of Intellect in Virtue" (Proceedings of the Aristotelian Society 74 l t973-74]:t t6), says that he has noticed sixteen commentators who take this view. [4o5] 406 HISTORY OF PHILOSOPHY so-called formal account of prohairesis (NE 3. 2-3, 6. 2), the object of choice is what has been decided upon by deliberation (bouleuais), and what is decided upon by deliberation is a "means" to an end. 2. Aristotle says that choice is "closely bound up with virtue" and "discriminates characters better than actions do" (1 1t lb5; cf. t i lob3t, 1117a 5, 1163a22, 1t64bi); but commentators argue that these claims about choice are false unless choice is "of ends." 3. Though Aristotle holds that the impetuous akrat~s (incontinent agent) does not deliberate (e.g., t 152a 18-19), he says that the akrat~s' choice is good (1152ax5--17; cf. l l51a5-- 7, 29--32); and this appears to contradict his position in Book 3 that the object of choice is what is decided upon by deliberation, s In this paper I shall show that only one (philosophically significant) notion ofprohairesis is employed in the NE, namely, the notion developed in the "formal account" of deliberation and choice (3- 2-3, 6. 2), according to which choice is specifically of things which are pros ends. This point has several interesting applications. For example, it makes it easier to find in Aristotle (as I shall briefly explain) a comprehensive theory of practical reasoning or inference rather than several unconnected accounts of what practical inference is like in different types of cases; and it is helpful in clarifying what is involved in the evaluation of character on Aristotle's view (see Sec. ~). However, though I do think that the main point to be made... (shrink)

Johann Friedrich Ludwig Schröder (1774-1845 ) was born in Germany but moved to Holland at the age of 13. After studying at Halle he joined the Kantian movement in Amsterdam as an active member, cooperating with Paulus van Hemert and contributing articles to his Kantian magazine. During his professional career as a marine instructor (1803-11 ), however, he became increasingly critical of Kantianism. As professor of mathematics, physics and philosophy at the University of Utrecht (1816-44) he traded in his former (...) Kantianism for a variant of the common sense philosophy then in favour in the Netherlands. He now regarded Kantianism as a form of scepticism. Accordingly, in his major work, the Contnbution to a Critique of the Truth of Human Knowledge, he propounds an anti-sceptical doctrine of such ‘basic truths’ as are founded on the immediate relevation of our consciousness. Schröder also attempts to reduce the Kantian doctrine of the noumenon to an inconsistent set of propositions, by showing them to be antinomies in the Kantian sense of the term, even using Kant's own dialectical method in proving their contradictoriness ; these contradictory propositions he calls the 'antinomies of the Kantian philosophy'. In a minor work, The Sign Relation as the Basis of Human Knowledge (translated freely), we find reminiscences of Thomas Reid's Inquiry into the Human Mind: of the doctrine of sensations suggesting our conceptions of things, of causes being the signs of their effects, of 'the natural language of mankind'. Schröder, in developing these ideas in his own way, presents the sign relation as being fundamental to the construction of our knowledge of both nature and the human soul. Only by taking one thing as the ‘sign’ (signal, symbol, symptom, index, expression, picture, representation etc.) of another can we attain a conception of the world as a coherent whole. Our perception of this relation is partly a matter of innate capacities, partly the result of acquired skill. (shrink)

This paper attempts to explore a number of conceptual issues surrounding genetic testing. It looks at the meaning of the terms, genetic information and genetic testing in relation to the definition set out by the Advisory Committee on Genetic Testing in the UK, and by the Task Force on Genetic Testing in the USA. It argues that the special arrangements that may be required for the regulation of genetic tests should not be determined by reference to the nature or technology (...) of the test, but by considering those morally relevant features that justify regulation. Failure to do so will lead to the regulation of genetic tests that need not be regulated, and would fail to cover other tests which should be regulated. The paper also argues that there is little in the nature of the properties of gene tests, using DNA or chromosomes, that in itself justifies a special approach. (shrink)

The understanding of value in moral naturalism as a descriptivist endeavor will be analized through an application of the naturalistic fallacy on an evolutive perspective of moral psychology. From a brief analysis of the naturalistic fallacy as proposed by Dall’Agnol, I’ll criticize the author’s application of such on what he refers to as moral naturalism. Contrasting E. Wilson’s sociobiology with R. Triver’s theory of reciprocal altruism I will procure a definition of naturalized ethics by investigating the psychological roots of moral (...) motivation. Once identified the descriptive and non-reductionist aspects of contemporary moral naturalism, the naturalistic fallacy presents itself as unbecoming of its hallmark and metaethical importance, and it becomes clear that a naturalized comprehension of human moral behavior is vital to the understanding of the motivations for action and the conception of value; though weak under a normative perspective. (shrink)

The notion of autonomy commonly employed in medical ethics literature and practices is inadequate on three fronts: it fails to properly identify nonautonomous actions and choices, it gives a false account of which features of actions and choices makes them autonomous or nonautonomous, and it provides no grounds for the moral requirement to respect autonomy. In this paper I offer a more adequate framework for how to think about autonomy, but this framework does not lend itself to the kinds of (...) practical application assumed in medical ethics. A general problem then arises: the notion of autonomy used in medical ethics is conceptually inadequate, but conceptually adequate notions of autonomy do not have the practical applications that are the central concern of medical ethics. Thus, a revision both of the view of autonomy and the practice of “respect for autonomy” are in order. (shrink)

Terrorism, international gangs, and other frequently mentioned national security threats are actually less dangerous than a new type of state-corporate crime that may be called national insecurity crime. This crime poses not only unprecedented victimization, but a massive ethical problem. Examples in the U.S. include the 1980s Savings and Loan (S&L) scandal, the late-1990s dot-com bubble, the 2003 U.S. invasion of Iraq, and the 2007–09 financial crisis. National insecurity crime threatens national security because of its geographic and social extensiveness, severity (...) of harm, dynamism, and unpredictability. It endangers the political, economic, social, and environmental security of most or all of the U.S. population. This endangerment includes increasing the risks of loss, suffering, and destruction on a large scale. This article offers a starting point for a sociological criminology of national insecurity crime. National insecurity crime involves large-scale cooperation that relies on often indirect or mediated interaction between perpetrating persons, groups, and organizations. It also involves widespread social harm for private gain, and yet, due to ideology and social construction, it tends to be hidden in plain sight. (shrink)

In this commentary on the article by Arthur L. Caplan [1] the philosophy of medicine is viewed from a medical perspective. Philosophical studies have a long tradition in medicine, especially during periods of paradigmatic unrest, and they serve the same goal as other medical activities: the prevention and treatment of disease. The medical profession needs the help of professional philosophers in much the same way as it needs the cooperation of basic scientists. Philosophy of medicine may not deserve the status (...) of a philosophical subspecialty or field, but it so closely linked to the main trends of contemporary medical thinking that it must be regarded as an emerging (or reemerging) medical subdiscipline. (shrink)

Alberto Cortes, in [1], attempts to show that Leibniz's Principle of The Identity of Indiscernibles is a principle restricted to individuals, and that photons appear to violate L. L is stated by Leibniz as “no two substances are completely similar, or differ solo numero.” In second-order quantification theory with identity L becomes.